Role of Fenugreek, Cinnamon, Curcuma longa, Berberine and Momordica charantia in Type 2 Diabetes Mellitus Treatment: A Review.

Pharmaceuticals (Basel, Switzerland). 2023;16(4)
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Type 2 diabetes (T2D) is a global health concern. Treatments are often associated with side effects and high costs and therefore it has been identified that there is a need for alternatives. Traditional medicines such as fenugreek, cinnamon, Curcuma longa, berberine, and Momordica charantia have all demonstrated the potential to help control high blood sugar. This review study aimed to summarise the evidence for the use of these traditional medicines in individuals with T2D. Fenugreek was found to act through suppressing the digestion and absorption of starch and inhibiting the uptake of sugar. Its high fibre content is thought to be responsible for slowing the rate of digestion. It is also thought that fenugreek can regulate enzymes involved in the formation of sugar within the body. Studies in animal models have also shown that it may improve insulin function, which is a hormone responsible for lowering blood sugar. These effects translated into clinical evidence of blood sugar lowering and there is significant research demonstrating blood sugar lowering in humans. Cinnamon was found to act through suppressing the digestion and absorption of carbohydrates and improved insulin function. There were several clinical studies reviewed showing that in humans cinnamon can lower blood sugar levels and improve measures of T2D. Curcuma longa (turmeric) was found to suppress production and increase storage of sugar in the liver. It was also found to improve insulin function. In clinical studies it was shown to decrease blood sugar levels, improve measures of T2D and prevent T2D development in those with prediabetes. Berberine was found to exhibit antidiabetic effects through modulation of the gut microbiota and by inhibiting fat accumulation resulting in better insulin function. Several clinical trials were reviewed showing that berberine improved blood sugar levels and measures of T2D. Momordica charantia, commonly known as bitter melon was found to suppress sugar uptake following digestion and improve metabolism by regulating key enzymes. In humans it was shown to increase insulin levels and decrease blood sugar and improve measures of T2D. It was concluded that all these traditional plants have the potential to be used as an alternative or complementary therapy for T2D, however further research is warranted. This study could be used by healthcare professionals to look at introducing these therapies to individuals who have uncontrolled T2D or who are suffering with side effects from medications.

Abstract

Type 2 diabetes mellitus (T2DM) is a complex disease that has become a major global health concern. Given the efficacy of antidiabetic drugs, pharmacological therapy is considered the first-line treatment of T2DM; however, due to their potential side effects and high costs, new and cost-effective treatments with minimal side effects are needed. Medicinal plants have been used for centuries as part of traditional medicine to treat T2DM. Among these, fenugreek, cinnamon, Curcuma longa, berberine, and Momordica charantia have demonstrated different degrees of hypoglycemic activity in clinical studies and animal models. Therefore, the aim of this review is to synthesize the mechanisms of action of five medicinal plants, as well as the experimental and clinical evidence of their hypoglycemic activity from the published literature.

Lifestyle medicine

Fundamental Clinical Imbalances : Hormonal ; Immune and inflammation
Patient Centred Factors : Mediators/Blood sugar imbalance
Environmental Inputs : Diet ; Nutrients
Personal Lifestyle Factors : Nutrition
Functional Laboratory Testing : Not applicable
Bioactive Substances : Cinnamon ; Fenugreek ; Turmeric ; Berberine ; Momordica charantia

Methodological quality

Jadad score : Not applicable
Allocation concealment : Not applicable
Publication Type : Journal Article ; Review

Metadata

Nutrition Evidence keywords : Insulin